The Stevens Lab NEWS:

December 7, 2016

"Researchers Reveal 3D Structure of Cellís Inflammation Sensor and its Inhibitors"Article in UC San Diego News about new structure of the C-C Chemokine Receptor 2
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October 20, 2016

Crystal Structure of the Human Cannabinoid Receptor CB 1 is published in Cell
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July 6, 2016

Congratulations to Ariel Wein on receiving 2-year Appointment to USC's T32 Graduate Student Training Grant "CBI: Chemical Biology Interface."

May, 2016

Congratulations to Rebecca Miller on receiving a "Ruth L. Kirschstein National Research Service Award Individual Graduate Fellowship"

May, 2016

Congratulations to David Manahan on receiving "Summer 2016 Rose Hills Undergraduate Research Fellowship"

May, 2016

Congratulations to Zhongying Wangon on receiving "The BISC Outstanding Teaching Assistant Award".

May, 2016

Congratulations to Dr. Kate White on receiving the competitive "WiSE Merit Award for Excellence in Postdoctoral Research".

April 4, 2016

Congratulations to Ariel Wein for receiving an Honorable Mention in the National Science Foundation Graduate Research Fellowship Program.

February 25, 2016

Ray Stevens was elected to the Norwegian Academy of Science and Letters.

February 18, 2016

The 1st Annual daVinci Convergence Symposium: A Scientific Summit on Imaging Across the Scales hosted by Bridge@USC at Annenberg Community Beach House, Santa Monica, CA, USA.
For more information and registration please contact Angela Walker: MORE>>
Symposium Program >>

October 29-31, 2015

Global Conference 2015, Grand Hyatt Shanghai ∑ Shanghai, China

September 9, 2015

Los Angeles and Shanghai - GPCR Consortium Exceeds Goal with Addition of Four New Pharma Members Academia and Industry Members Helping to Advance Structure-Function Database of G-protein Coupled Receptors for Drug Discovery

July 31, 2015

Conformational states of the full-length glucagon receptor is published in Nature Communications

July 30, 2015

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser is published in Nature

June 18, 2015

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 is published in Cell

June 10, 2015

Targeting Hearts. Inspired to find answers by her grandfather's heart disease, Tiffany Lian (laboratory of Professor Raymond Stevens, The Bridge@USC) is conducting research on taste receptors that may benefit drug discovery and development.

April 23, 2015

A Structure of the Angiotensin Receptor revealed by Serial Femtosecond Crystallography is published online in Cell

March 30, 2015

Structures of human P2Y1 receptor bring new excitement to GPCR research. SHANGHAI, CHINA - March 31, 2015 - A team of Chinese and US scientists has determined the high-resolution atomic structure of a cell-surface receptor that plays a critical role in thrombosis, or blood clot, formation. In a paper published in Nature on March 30 London time, the researchers at Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, collaborating with research groups from National Institutes of Health (NIH, U.S.), Bridge Institute at University of Southern California (U.S.) and iHuman Institute of ShanghaiTech University (China), provide a detailed molecular map of the human P2Y1 receptor (P2Y1R), a GPCR, in complex with a nucleotide antagonist MRS2500 and a non-nucleotide antagonist BPTU.

March 2, 2015

The Bridge@USC brochure is now available online.

February 10, 2015

LOS ANGELES and SHANGHAI, /PRNewswire/ - The GPCR Consortium, an international nonprofit collaboration that comprises leading academic research institutes in the United States and China and major pharmaceutical companies from around the world, today announced two new members. Novo Nordisk and Merck & Co., Inc, known as MSD outside the United States and Canada, have joined Amgen, Sanofi and Ono in the GPCR Consortium, bringing the current pharma membership to five. The research funded by the GPCR Consortium is currently conducted
at the Bridge Institute at the University of Southern California, Shanghai Institute of Materia Medica, and the iHuman Institute at ShanghaiTech University.


January 23, 2015

Researchers at Bridge Institute at the University of Southern California and University of California,
San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences report the first crystal structure of the cellular receptor CXCR4 bound to an immune signaling protein called a chemokine. The structure, published Jan. 22 in Science, answers longstanding questions about a molecular interaction that plays an important role in human development, immune responses, cancer metastasis and HIV infections.

January 6, 2015

Cherezov, Katritch, and Stevens 2014 Nature paper on δ-opioid and sodium signaling noted as one of the Science Signaling Breakthroughs of the Year.

January 1, 2015

Cherezov, Katritch, Kuhn and Stevens Labs move to the University of Southern California to start up
a NEW convergent biosciences institute

December 4, 2014

GPCR Consortium Plans – An open source industry-academia GPCR Consortium has been organized to accelerate GPCR structure-function studies

October 28, 2014

Los Angeles and Shanghai - New International GPCR Consortium Formed with Pharma and Academia to Advance Structural Information about G-protein Coupled Receptors

October 27, 2014

GPCR Industry-Academia Consortium announced

October 23, 2014

USC Michelson Convergence Building groundbreaking

August 5, 2014

Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment in Structure

July 10, 2014

Publication of Structural Basis for Smoothened Receptor Modulation and Chemoresistance to Anticancer Drugs in the journal Nature Communications

May 1, 2014

Two publications of the human P2Y12 receptors in the journal Nature
Agonist-bound P2Y12
Antagonist -bound P2Y12

April 21, 2014

Review on allosteric role of sodium in class A GPCR signaling in TiBS on-line

March 23, 2014

Publication of Structure of the human P2Y12 receptor in the journal Nature

March 6, 2014

Publication of Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 in the journal Science

January 12, 2014

Publication of Molecular Control of δ-Opioid Receptor Signalling in the journal Nature

December 20, 2013

Publication of Serial Femtosecond Crystallography of G-Protein-Coupled Receptors in the journal Science

September 12, 2013

Publication of structure of the Human CCR5 Chemokine G-protein-coupled Receptor in the journal Science

July 17, 2013

Publication of Structure of the Human Glucagon Class B G-protein-coupled Receptor in the journal Nature

May 1, 2013

Publication of structure of the Human Smoothened Receptor in the journal Nature

March 21, 2013

Publication of two Serotonin receptors structures 5-HT1B
and 5-HT2Bin the journal Science

Serotonin 5-HT1B >>
Serotonin 5-HT2B >>

January 24, 2013

GPCR Dock 2013 starts February 1st.
Spread the word and Register NOW at>>

November 26, 2012

SAB meetings for JCIMPT and GPCR Network to plan for the future.

August 24, 2012

Due to repeated requests for figures and artwork, popular items are being made available to the community for use. You can download them HERE>>

August 1, 2012

Congratulations TSRI graduate student
Eugene Chun on receiving the 2012 Margaret C. Etter student award from the BioMacromolecular Special Interest Group at ACA for his work on the membrane protein (GPCR) fusion toolchest

July 13, 2012

GPCRs as allosteric machines controlled by sodium, cholesterol, lipids, water in Science

June 5, 2012

New Fusion Protein Toolbox for membrane protein structural biology in Structure

May 17, 2012

Special issue of Nature highlighting all four opioid receptor crystal structures
kappa_opioid >>
mu_opioid >>
nociceptin >>
delta_opioid >>

March 21, 2012

Publication of kappa-opioid receptor structure in the journal Nature
For details click HERE >>

February 17, 2012

Publication of S1P1 receptor structure in the journal Science
For details click HERE >>

January 19, 2012

Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR - in Science Express

January 12, 2012

TiPS review on GPCR structural diversity and modularity

September 23, 2011

GPCR Network and JCIMPT-Complexes announce their Center and Scientific Advisory Board meetings to be held November 28-29, 2011 at TSRI

August 3, 2011

Wednesday, August 3, 2011 - PSI:Biology GPCR Network structure researchers hold first annual GPCR Network meeting.

June 22, 2011

In an international collaboration with the Iwata laboratory, the human Histamine H1 receptor structure solved with 1st generation antihistamine. MORE >>

May 12, 2011

GPCR Network Assessment Opens - ligand selection for opioid receptor MORE >>

March 10, 2011

Agonist bound structure of the A2A adenosine receptor highlights “conformationally selective agonist” published in Science Express. more >>

Movie >>

MOVIE: Conformational morphing trajectory between inactive, antagonist bound (yellow) and active, agonist bound (orange) forms of A2A adenosine receptor.
Re: Xu, F., Wu, H., Katritch, V., Han, G.W., Jacobson, K.A., Gao, Z.G., Cherezov, V. and R,C. Stevens. (2011)
Structure of an agonist-bound human A2A adenosine receptor. Science Express, March 10, 2011. Movie prepared with ICM-Pro (Molsoft LLC).

November 19, 2010

The structures of the human chemokine CXCR4 and dopamine D3 are reported in Science
CXCR4 Structure >>
D3 Structure >>

November 17-18, 2010

3rd Annual NIH Roadmap to High Resolution Membrane Protein Structures Meeting to be held in La Jolla.
In addition, a special LCP hands on tools workshop will be held November 16th at the Scripps Research Institute led by Professor Vadim Cherezov.
For information, see more>>

October 7, 2010

5 structures of human CXCR4 chemokine GPCR published in Science more>>

September 20, 2010

The PSI:Biology GPCR Network conquers Mt Whitney during kick-off retreat.
During the first annual GPCR Network retreat, 10 members of the group climbed to the top of Mt Whitney, the highest peak in the continental United States at 14,505 feet. All members returned safely to continue building the GPCR Network.

September 14, 2010

GPCR Network established as a part of the NIH PSI:Biology program. For more information, see more>>

July 30, 2010

GPCR Dock 2010 assessment now closed to depositions, results to be announced in the early fall. For more information, please see more>>

June 4, 2010

GPCR Dock 2010 announced to evaluate the progress of GPCR modeling and docking in CXCR4 and D3 receptors. For more information, please see more>>

>February 1, 2010

3rd Annual NIH Roadmap meeting for membrane protein technologies Nov 17-18th in La Jolla more>>

> January 22, 2010

In collaboration with colleagues at UCSD and Leiden University,
structure based discovery of novel chemotypes for Adenosine A2A receptor antagonists more>>

> January 8, 2010

In collaboration with colleagues at Scripps Florida, dynamics of the human β2-adrenergic receptor revealed by hydrogen-deuterium exchange more>>

> June 1, 2009

Analysis of the GPCR Dock 2008 assessment is published in Nature Reviews Drug Discovery

> April 23, 2009

Scientists from the Stevens lab and Cravatt lab in collaboration with Pfizer,
Inc. discovered a potential new painkiller.

> January 16, 2009

Membrane Protein Postdoctoral Research Associate position available immediately more>>

> October 2, 2008

The Stevens Lab determined a 2.6 A structure of the human adenosine A2a receptor.

> June 11, 2008

The Stevens Lab established a Cholesterol Consensus Motif in GPCRs. more>>

> October 25, 2007

The Stevens Lab solved a high-resolution structure of the human beta2-adrenergic receptor in collaboration with Kobilka Lab from Stanford University.